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TitleStructural insights into the activation of P. vivax plasmepsin.
Journal, issue, pagesJ. Mol. Biol., Vol. 329, Page 505-524, Year 2003
Publish dateAug 23, 2002 (structure data deposition date)
AuthorsBernstein, N.K. / Cherney, M.M. / Yowell, C.A. / Dame, J.B. / James, M.N.
External linksJ. Mol. Biol. / PubMed:12767832
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1miq:
Crystal structure of proplasmepsin from the human malarial pathogen Plasmodium vivax
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1qs8:
Crystal structure of the P. vivax aspartic proteinase plasmepsin complexed with the inhibitor pepstatin A
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

Source
  • plasmodium vivax (malaria parasite P. vivax)
  • streptomyces argenteolus subsp. toyonakensis (bacteria)
KeywordsHYDROLASE / aspartic proteinase zymogen / domain opening / HYDROLASE/HYDROLASE INHIBITOR / PLASMEPSIN / ASPARTIC PROTEINASE / HAEMOGLOBINASE / MALARIA / PEPSTATIN A / HYDROLASE-HYDROLASE INHIBITOR complex

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