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TitleMimicking Natural Evolution in Vitro: An N-Acetylneuraminate Lyase Mutant with an Increased Dihydrodipicolinate Synthase Activity
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 100, Page 5694-, Year 2003
Publish dateMar 12, 2003 (structure data deposition date)
AuthorsJoerger, A.C. / Mayer, S. / Fersht, A.R.
External linksProc. Natl. Acad. Sci. USA / PubMed:12711733
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-1hl2:
Crystal structure of N-acetylneuraminate lyase from E. coli mutant L142R in complex with b-hydroxypyruvate
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-3PY:
3-HYDROXYPYRUVIC ACID

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsLYASE / N-ACETYLNEURAMINATE LYASE / CLASS I ALDOLASE / CARBOHYDRATE METABOLISM / SCHIFF BASE

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