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-Structure paper
Title | Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 13, Page 1571-1574, Year 2003 |
Publish date | Dec 20, 2002 (structure data deposition date) |
![]() | Tong, Y. / Lin, N.H. / Wang, L. / Hasvold, L. / Wang, W. / Leonard, N. / Li, T. / Li, Q. / Cohen, J. / Gu, W.Z. ...Tong, Y. / Lin, N.H. / Wang, L. / Hasvold, L. / Wang, W. / Leonard, N. / Li, T. / Li, Q. / Cohen, J. / Gu, W.Z. / Zhang, H. / Stoll, V. / Bauch, J. / Marsh, K. / Rosenberg, S.H. / Sham, H.L. |
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Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | ![]() PDB-1ni1: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-HFP: ![]() ChemComp-2C5: |
Source |
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![]() | TRANSFERASE / Prenyltransferase / FTASE / cyanophenyl |