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TitleDiscovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 13, Page 1571-1574, Year 2003
Publish dateDec 20, 2002 (structure data deposition date)
AuthorsTong, Y. / Lin, N.H. / Wang, L. / Hasvold, L. / Wang, W. / Leonard, N. / Li, T. / Li, Q. / Cohen, J. / Gu, W.Z. ...Tong, Y. / Lin, N.H. / Wang, L. / Hasvold, L. / Wang, W. / Leonard, N. / Li, T. / Li, Q. / Cohen, J. / Gu, W.Z. / Zhang, H. / Stoll, V. / Bauch, J. / Marsh, K. / Rosenberg, S.H. / Sham, H.L.
External linksBioorg. Med. Chem. Lett. / PubMed:12699757
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-1ni1:
Imidazole and cyanophenyl farnesyl transferase inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HFP:
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID

ChemComp-2C5:
2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSFERASE / Prenyltransferase / FTASE / cyanophenyl

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