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TitleThyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.
Journal, issue, pagesJ. Med. Chem., Vol. 46, Page 1580-1588, Year 2003
Publish dateNov 29, 2002 (structure data deposition date)
AuthorsYe, L. / Li, Y.L. / Mellstrom, K. / Mellin, C. / Bladh, L.G. / Koehler, K. / Garg, N. / Garcia Collazo, A.M. / Litten, C. / Husman, B. ...Ye, L. / Li, Y.L. / Mellstrom, K. / Mellin, C. / Bladh, L.G. / Koehler, K. / Garg, N. / Garcia Collazo, A.M. / Litten, C. / Husman, B. / Persson, K. / Ljunggren, J. / Grover, G. / Sleph, P.G. / George, R. / Malm, J.
External linksJ. Med. Chem. / PubMed:12699376
MethodsX-ray diffraction
Resolution2.5 - 2.7 Å
Structure data

PDB-1nav:
Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1nax:
Thyroid receptor beta1 in complex with a beta-selective ligand
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-IH5:
{3,5-DICHLORO-4-[4-HYDROXY-3-(PROPAN-2-YL)PHENOXY]PHENYL}ACETIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Nuclear receptor / Thyroid receptor / ligand / complex

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