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-Structure paper
Title | The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 100, Page 5063-5068, Year 2003 |
Publish date | Mar 16, 2003 (structure data deposition date) |
Authors | Engel, M. / Hoffmann, T. / Wagner, L. / Wermann, M. / Heiser, U. / Kiefersauer, R. / Huber, R. / Bode, W. / Demuth, H.U. / Brandstetter, H. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:12690074 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.84 Å |
Structure data | PDB-1orv: PDB-1orw: |
Chemicals | ChemComp-NAG: ChemComp-SO4: ChemComp-HOH: ChemComp-PHI: ChemComp-P2Y: |
Source |
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Keywords | HYDROLASE / serine protease / oxyanion hole / substrate channeling / drug design / diabetes mellitus |