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TitleSynthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar
Journal, issue, pagesJ. MED. CHEM., Vol. 46, Page 1306-1317, Year 2003
Publish dateFeb 14, 2003 (structure data deposition date)
AuthorsEbdrup, S. / Pettersson, I. / Rasmussen, H.B. / Deussen, H.-J. / Frost Jensen, A. / Mortensen, S.B. / Fleckner, J. / Pridal, L. / Nygaard, L. / Sauerberg, P.
External linksJ. MED. CHEM. / PubMed:12672231
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-1nyx:
Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-DRF:
(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / PPAR / nuclear receptor / gene regulation / agonist complex

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