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TitleAryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 13, Page 1363-1366, Year 2003
Publish dateNov 22, 2002 (structure data deposition date)
AuthorsGwaltney II, S.L. / O'Connor, S.J. / Nelson, L.T. / Sullivan, G.M. / Imade, H. / Wang, W. / Hasvold, L. / Li, Q. / Cohen, J. / Gu, W.Z. ...Gwaltney II, S.L. / O'Connor, S.J. / Nelson, L.T. / Sullivan, G.M. / Imade, H. / Wang, W. / Hasvold, L. / Li, Q. / Cohen, J. / Gu, W.Z. / Tahir, S.K. / Bauch, J. / Marsh, K. / Ng, S.C. / Frost, D.J. / Zhang, H. / Muchmore, S. / Jakob, C.G. / Stoll, V. / Hutchins, C. / Rosenberg, S.H. / Sham, H.L.
External linksBioorg. Med. Chem. Lett. / PubMed:12657283
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-1n9a:
Farnesyltransferase complex with tetrahydropyridine inhibitors
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HFP:
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID

ChemComp-FTI:
1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE

Source
  • rattus norvegicus (Norway rat)
KeywordsTRANSFERASE / Farnesyltransferase / tetrahydropyridine / Prenyltransferase

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