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-Structure paper
| Title | Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides. |
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| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 13, Page 1353-1357, Year 2003 |
| Publish date | Sep 23, 2002 (structure data deposition date) |
 Authors | Burgey, C.S. / Robinson, K.A. / Lyle, T.A. / Nantermet, P.G. / Selnick, H.G. / Isaacs, R.C. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Singh, R. ...Burgey, C.S. / Robinson, K.A. / Lyle, T.A. / Nantermet, P.G. / Selnick, H.G. / Isaacs, R.C. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Singh, R. / Miller-Stein, C. / White, R.B. / Wong, B. / Lyle, E.A. / Stranieri, M.T. / Cook, J.J. / McMasters, D.R. / Pellicore, J.M. / Pal, S. / Wallace, A.A. / Clayton, F.C. / Bohn, D. / Welsh, D.C. / Lynch, J.J. / Yan, Y. / Chen, Z. / Kuo, L. / Gardell, S.J. / Shafer, J.A. / Vacca, J.P. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:12657281 |
| Methods | X-ray diffraction |
| Resolution | 2 Å |
| Structure data |  PDB-1mue: |
| Chemicals |  ChemComp-CDD:  ChemComp-HOH: |
| Source |
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 Keywords | HYDROLASE INHIBITOR / alpha thrombin-hirugen / BLOOD CLOTTING COMPLEX / HYDROLASE INHIBITOR COMPLEX |
homo sapiens (human)
hirudo medicinalis (medicinal leech)