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TitleStructural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex
Journal, issue, pagesJ. Biol. Chem., Vol. 278, Page 12461-12466, Year 2003
Publish dateDec 18, 2002 (structure data deposition date)
AuthorsChrencik, J.E. / Burgin, A.B. / Pommier, Y. / Stewart, L. / Redinbo, M.R.
External linksJ. Biol. Chem. / PubMed:12533542
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-1nh3:
Human Topoisomerase I Ara-C Complex
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE/DNA / Ara-C / protein-DNA complex / DNA damage / isomerase / ISOMERASE-DNA COMPLEX

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