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TitleCompetitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.
Journal, issue, pagesJ. Med. Chem., Vol. 46, Page 214-221, Year 2003
Publish dateOct 15, 2002 (structure data deposition date)
AuthorsHogner, A. / Greenwood, J.R. / Liljefors, T. / Lunn, M.L. / Egebjerg, J. / Larsen, I.K. / Gouaux, E. / Kastrup, J.S.
External linksJ. Med. Chem. / PubMed:12519060
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-1n0t:
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution.
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-AT1:
(S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / Ionotropic glutamate receptor GluR2 / ligand-binding core / antagonist complex

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