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Structure paper

TitleStructural Basis for Imipenem Inhibition of Class C beta-lactamases
Journal, issue, pagesANTIMICROB. AGENTS CHEMOTHER., Vol. 46, Page 3978-3980, Year 2002
Publish dateApr 26, 2002 (structure data deposition date)
AuthorsBeadle, B.M. / Shoichet, B.K.
External linksANTIMICROB. AGENTS CHEMOTHER. / PubMed:12435704
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-1ll5:
X-ray crystal structure of AmpC WT beta-lactamase in complex with covalently bound imipenem
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-IM2:
(5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox / antibiotic*YM

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / beta-lactamase / carbapenem / imipenem

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