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Title2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2'-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA
Journal, issue, pagesBiochemistry, Vol. 41, Page 11642-11648, Year 2002
Publish dateAug 31, 2002 (structure data deposition date)
AuthorsPrakash, T.P. / Manoharan, M. / Kawasaki, A.M. / Fraser, A.S. / Lesnik, E.A. / Sioufi, N. / Leeds, J.M. / Teplova, M. / Egli, M.
External linksBiochemistry / PubMed:12269806
MethodsX-ray diffraction
Resolution1.25 Å
Structure data

PDB-1mlx:
Crystal Structure Analysis of a 2'-O-[2-(Methylthio)-ethyl]-Modified Oligodeoxynucleotide Duplex
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

Chemicals

ChemComp-HOH:
WATER

KeywordsDNA / DOUBLE HELIX / A-FORM / ANTISENSE MODIFICATION / NUCLEIC ACID ANALOGUE / RNA AFFINITY / NUCLEASE RESISTANCE / PROTEIN BINDING AFFINITY / HIGH RESOLUTION STRUCTURE / HYDRATION

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