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Structure paper

Title8-Oxoguanine rearranges the active site of human topoisomerase I
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 99, Page 12102-12107, Year 2002
Publish dateMay 8, 2002 (structure data deposition date)
AuthorsLesher, D.T. / Pommier, Y. / Stewart, L. / Redinbo, M.R.
External linksProc. Natl. Acad. Sci. USA / PubMed:12209008
MethodsX-ray diffraction
Resolution3.14 Å
Structure data

PDB-1lpq:
Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion
Method: X-RAY DIFFRACTION / Resolution: 3.14 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE/DNA / protein-DNA complex / DNA damage / induced conformational change / ISOMERASE-DNA COMPLEX

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