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TitleCrystal Structure of an in Vitro Affinity- and Specificity-matured Anti-testosterone Fab in Complex with Testosterone. IMPROVED AFFINITY RESULTS FROM SMALL STRUCTURAL CHANGES WITHIN THE VARIABLE DOMAINS
Journal, issue, pagesJ. Biol. Chem., Vol. 277, Page 44021-44027, Year 2002
Publish dateMar 17, 2002 (structure data deposition date)
AuthorsValjakka, J. / Hemminki, A. / Niemi, S. / Soderlund, H. / Takkinen, K. / Rouvinen, J.
External linksJ. Biol. Chem. / PubMed:12196551
MethodsX-ray diffraction
Resolution2.1 - 2.15 Å
Structure data

PDB-1l7t:
Crystal Structure Analysis of the anti-testosterone Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-1vpo:
Crystal Structure Analysis of the Anti-testosterone Fab in Complex with Testosterone
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-TES:
TESTOSTERONE / hormone*YM

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / anti-testosterone / fab fragment / affinity and specificity matured / anti-steroid / testosterone complex

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