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Structure paper

TitleAminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates.
Journal, issue, pagesNat. Struct. Biol., Vol. 9, Page 653-658, Year 2002
Publish dateJul 2, 2002 (structure data deposition date)
AuthorsVetting, M.W. / Hegde, S.S. / Javid-Majd, F. / Blanchard, J.S. / Roderick, S.L.
External linksNat. Struct. Biol. / PubMed:12161746
MethodsX-ray diffraction
Resolution1.5 - 1.8 Å
Structure data

PDB-1m44:
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1m4d:
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1m4g:
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Ribostamycin
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1m4i:
Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Kanamycin A
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-TOY:
TOBRAMYCIN / antibiotic*YM

ChemComp-COA:
COENZYME A

ChemComp-PAP:
3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE

ChemComp-RIO:
RIBOSTAMYCIN / antibiotic*YM

ChemComp-KAN:
KANAMYCIN A / antibiotic*YM

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsTRANSFERASE / COA BINDING MOTIF

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