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Structure paper

TitleStructural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Journal, issue, pagesNature, Vol. 417, Page 975-978, Year 2002
Publish dateMay 9, 2002 (structure data deposition date)
AuthorsHon, W.C. / Wilson, M.I. / Harlos, K. / Claridge, T.D. / Schofield, C.J. / Pugh, C.W. / Maxwell, P.H. / Ratcliffe, P.J. / Stuart, D.I. / Jones, E.Y.
External linksNature / PubMed:12050673
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1lqb:
Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / protein-peptide complex / tumor suppressor / cancer / proteosomal degradation / ubiquitin / prolyl hydroxylation

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