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Structure paper

TitleCrystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase.
Journal, issue, pagesJ. Biol. Chem., Vol. 277, Page 28080-28087, Year 2002
Publish dateMay 6, 2002 (structure data deposition date)
AuthorsWu, N. / Pai, E.F.
External linksJ. Biol. Chem. / PubMed:12011084
MethodsX-ray diffraction
Resolution1.5 - 1.9 Å
Structure data

PDB-1lol:
Crystal structure of orotidine monophosphate decarboxylase complex with XMP
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1loq:
Crystal structure of orotidine monophosphate decarboxylase complexed with product UMP
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-1lor:
crystal structure of orotidine 5'-monophosphate complexed with BMP
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1los:
crystal structure of orotidine monophosphate decarboxylase mutant deltaR203A complexed with 6-azaUMP
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1lp6:
Crystal structure of orotidine monophosphate decarboxylase complexed with CMP
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-BU2:
1,3-BUTANEDIOL

ChemComp-XMP:
XANTHOSINE-5'-MONOPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-U5P:
URIDINE-5'-MONOPHOSPHATE

ChemComp-BMP:
6-HYDROXYURIDINE-5'-PHOSPHATE

ChemComp-UP6:
6-AZA URIDINE 5'-MONOPHOSPHATE

ChemComp-C5P:
CYTIDINE-5'-MONOPHOSPHATE

Source
  • methanothermobacter thermautotrophicus str. delta h (archaea)
  • archaea (unknown)
  • methanothermobacter thermautotrophicus (archaea)
KeywordsLYASE / TIM barrel

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