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TitleThe Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents
Journal, issue, pagesJ. Biol. Chem., Vol. 277, Page 24976-24982, Year 2002
Publish dateApr 22, 2002 (structure data deposition date)
AuthorsLubetsky, J.B. / Dios, A. / Han, J. / Aljabari, B. / Ruzsicska, B. / Mitchell, R. / Lolis, E. / Al-Abed, Y.
External linksJ. Biol. Chem. / PubMed:11997397
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1ljt:
Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HDI:
3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / protein-inhibitor complex

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