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TitleStructural insights into CPT-11 activation by mammalian carboxylesterases.
Journal, issue, pagesNat. Struct. Biol., Vol. 9, Page 337-342, Year 2002
Publish dateOct 9, 2001 (structure data deposition date)
AuthorsBencharit, S. / Morton, C.L. / Howard-Williams, E.L. / Danks, M.K. / Potter, P.M. / Redinbo, M.R.
External linksNat. Struct. Biol. / PubMed:11967565
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1k4y:
Crystal Structure of Rabbit Liver Carboxylesterase in Complex with 4-piperidino-piperidine
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-4PN:
4-PIPERIDINO-PIPERIDINE

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
KeywordsHYDROLASE / ESTERASE / SIDE DOOR / CAMPTOTHECIN / IRINOTECAN

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