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Structure paper

TitleInteraction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha.
Journal, issue, pagesJ. Biol. Chem., Vol. 277, Page 21862-, Year 2002
Publish dateMar 22, 2002 (structure data deposition date)
AuthorsWarnmark, A. / Treuter, E. / Gustafsson, J.-A. / Hubbard, R.E. / Brzozowski, A.M. / Pike, A.C.W.
External linksJ. Biol. Chem. / PubMed:11937504
MethodsX-ray diffraction
Resolution2.4 - 2.45 Å
Structure data

PDB-1gwq:
HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE CORE AND TIF2 NRBOX2 PEPTIDE
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-1gwr:
HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-OESTRADIOL AND TIF2 NRBOX3 PEPTIDE
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-ZTW:
RALOXIFENE CORE

ChemComp-HOH:
WATER

ChemComp-EST:
ESTRADIOL / hormone*YM

Source
  • homo sapiens (human)
KeywordsNUCLEAR RECEPTOR / TRANSCRIPTION FACTOR / TRANSACTIVATION / AGONIST / AF2 COACTIVATOR / RECEPTOR / ACTIVATOR / TRANSCRIPTI REGULATION / DNA-BINDING / NUCLEAR PROTEIN / ZINC FINGER / STER BINDING / PHOSPHORYLATION / POLYMORPHISM / ALTERNATIVE SPLICIN / ALTERNATIVE SPLICING

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