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TitleStructural Basis for the Glucocorticoid Response in a Mutant Human Androgen Receptor (Ar(Ccr)) Derived from an Androgen-Independent Prostate Cancer
Journal, issue, pagesJ. Med. Chem., Vol. 45, Page 1439-1446, Year 2002
Publish dateDec 27, 2001 (structure data deposition date)
AuthorsMatias, P.M. / Carrondo, M.A. / Coelho, R. / Thomaz, M. / Zhao, X.-Y. / Wegg, A. / Crusius, K. / Egner, U. / Donner, P.
External linksJ. Med. Chem. / PubMed:11906285
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-1gs4:
Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-ZK5:
9ALPHA-FLUOROCORTISOL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANDROGEN RECEPTOR / HUMAN ANDROGEN RECEPTOR / LIGAND-BINDING DOMAIN / CORTISOL/ CORTISONE RESPONSE / PROSTATE CANCER

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