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Structure paper

TitleThe Methyl Group of N(Alpha)(Me)Arg-Containing Peptides Disturbs the Active-Site Geometry of Thrombin, Impairing Efficient Cleavage
Journal, issue, pagesJ. Mol. Biol., Vol. 316, Page 869-, Year 2002
Publish dateJul 18, 2001 (structure data deposition date)
AuthorsFriedrich, R. / Steinmetzer, T. / Huber, R. / Sturzebecher, J. / Bode, W.
External linksJ. Mol. Biol. / PubMed:11884127
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-1eb1:
Complex structure of human thrombin with N-methyl-arginine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / SERINE PROTEINASE / BLOOD COAGULATION / CALCIUM-BINDING / GLYCOPROTEIN / KRINGLE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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