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TitleStructure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
Journal, issue, pagesJ. Mol. Biol., Vol. 316, Page 277-289, Year 2002
Publish dateNov 19, 2001 (structure data deposition date)
AuthorsSchiffer, C.A. / Ultsch, M. / Walsh, S. / Somers, W. / De Vos, A.M. / Kossiakoff, A.A.
External linksJ. Mol. Biol. / PubMed:11851338
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-1kf9:
PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE/GROWTH FACTOR / CYTOKINE / HORMONE-RECEPTOR COMPLEX / PHAGE DISPLAY MOLECULAR PLASTICITY / RECEPTOR HOMODIMERIZATION / HUMAN GROWTH HORMONE / HORMONE-GROWTH FACTOR COMPLEX

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