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Structure paper

TitleStructures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Journal, issue, pagesBiochemistry, Vol. 40, Page 12826-12832, Year 2001
Publish dateSep 4, 2001 (structure data deposition date)
AuthorsAoyagi, M. / Arvai, A.S. / Ghosh, S. / Stuehr, D.J. / Tainer, J.A. / Getzoff, E.D.
External linksBiochemistry / PubMed:11669619
MethodsX-ray diffraction
Resolution2.3 - 2.6 Å
Structure data

PDB-1jwj:
Murine Inducible Nitric Oxide Synthase Oxygenase Dimer (Delta 65) with W457F Mutation at Tetrahydrobiopterin Binding Site
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-1jwk:
Murine Inducible Nitric Oxide Synthase Oxygenase Dimer (Delta 65) with W457A Mutation at Tetrahydrobiopterin Binding Site
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-H4B:
5,6,7,8-TETRAHYDROBIOPTERIN / neurotransmitter*YM

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-HBI:
7,8-DIHYDROBIOPTERIN

Source
  • mus musculus (house mouse)
KeywordsOXIDOREDUCTASE / Nitric Oxide L-Arginine Monooxygenase / Heme / Dimer / NOS / Tetrahydrobiopterin

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