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Structure paper

TitleStructure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.
Journal, issue, pagesStructure, Vol. 9, Page 699-706, Year 2001
Publish dateMar 9, 2001 (structure data deposition date)
AuthorsCronet, P. / Petersen, J.F. / Folmer, R. / Blomberg, N. / Sjoblom, K. / Karlsson, U. / Lindstedt, E.L. / Bamberg, K.
External linksStructure / PubMed:11587644
MethodsX-ray diffraction
Resolution2.2 - 2.35 Å
Structure data

PDB-1i7g:
CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN FROM HUMAN PPAR-ALPHA IN COMPLEX WITH THE AGONIST AZ 242
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1i7i:
CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST AZ 242
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-AZ2:
(2S)-2-ETHOXY-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENYL}ETHOXY)PHENYL]PROPANOIC ACID / agonist*YM

ChemComp-CPQ:
N,N-BIS(3-D-GLUCONAMIDOPROPYL)DEOXYCHOLAMIDE / detergent*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Anti parallel Helix Sandwich

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