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Structure paper

TitleSubstrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.
Journal, issue, pagesJ. Mol. Biol., Vol. 312, Page 731-742, Year 2001
Publish dateJul 11, 2001 (structure data deposition date)
AuthorsLang, R. / Kocourek, A. / Braun, M. / Tschesche, H. / Huber, R. / Bode, W. / Maskos, K.
External linksJ. Mol. Biol. / PubMed:11575928
MethodsX-ray diffraction
Resolution1.09 Å
Structure data

PDB-1jk3:
Crystal structure of human MMP-12 (Macrophage Elastase) at true atomic resolution
Method: X-RAY DIFFRACTION / Resolution: 1.09 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-BAT:
4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Matrix metalloproteinase / batimastat / bb94 / hydroxamic acid / MMP12 / elastase / complex (elastase-inhibitor) / metallo elastase

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