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TitleSolution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.
Journal, issue, pagesBiochemistry, Vol. 40, Page 10473-10484, Year 2001
Publish dateJul 26, 2001 (structure data deposition date)
AuthorsSubramaniam, G. / Paz, M.M. / Suresh Kumar, G. / Das, A. / Palom, Y. / Clement, C.C. / Patel, D.J. / Tomasz, M.
External linksBiochemistry / PubMed:11523988
MethodsNMR (solution)
Structure data

PDB-1jo1:
N7-Guanine Adduct of 2,7-diaminomitosene with DNA
Method: SOLUTION NMR

Chemicals

ChemComp-DAJ:
DECARBAMOYL-2,7-DIAMINOMITOSENE

KeywordsDNA / double helix / major groove binding drug / guanine-N7-alkylator

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