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Structure paper

TitlePteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites.
Journal, issue, pagesNat. Struct. Biol., Vol. 8, Page 521-, Year 2001
Publish dateSep 11, 2000 (structure data deposition date)
AuthorsGourley, D.G. / Schuttelkopf, A. / Leonard, G. / Luba, J. / Hardy, L. / Beverley, S. / Hunter, W.N.
External linksNat. Struct. Biol. / PubMed:11373620
MethodsX-ray diffraction
Resolution1.75 - 2.2 Å
Structure data

PDB-1e7w:
One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-1e92:
Pteridine reductase 1 from Leishmania major complexed with NADP+ and dihydrobiopterin
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-MTX:
METHOTREXATE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HBI:
7,8-DIHYDROBIOPTERIN

Source
  • leishmania major (eukaryote)
KeywordsOXIDOREDUCTASE / DIHYDROFOLATE REDUCTASE / PTERIDINE REDUCTASE / SHORTCHAIN DEHYDROGENASE / METHOTREXATE RESISTANCE / TRYPANOSOMATIDS / DRUG RESISTANCE / PTERIN SALVAGE / SHORT-CHAIN DEHYDROGENASE/REDUCTASE

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