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Structure paper

TitleHuman thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug
Journal, issue, pagesBiochemistry, Vol. 40, Page 1897-1902, Year 2001
Publish dateJan 8, 2001 (structure data deposition date)
AuthorsPhan, J. / Koli, S. / Minor, W. / Dunlap, R.B. / Berger, S.H. / Lebioda, L.
External linksBiochemistry / PubMed:11329255
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1hvy:
Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-D16:
TOMUDEX / chemotherapy, inhibitor*YM

ChemComp-UMP:
2'-DEOXYURIDINE 5'-MONOPHOSPHATE

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Tomudex / Raltitrexed

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