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| Title | Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 44, Page 1364-1371, Year 2001 |
| Publish date | May 1, 2000 (structure data deposition date) |
Authors | Shi, G. / Blaszczyk, J. / Ji, X. / Yan, H. |
External links | J. Med. Chem. / PubMed:11311059 |
| Methods | X-ray diffraction |
| Resolution | 1.85 Å |
| Structure data | ![]() PDB-1ex8: |
| Chemicals | ![]() ChemComp-MG: ![]() ChemComp-CL: ![]() ChemComp-A4P: ![]() ChemComp-HOH: |
| Source |
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Keywords | TRANSFERASE / PYROPHOSPHOKINASE / PYROPHOSPHORYL TRANSFER / FOLATE / HPPK / PTERIN / ATP / BISUBSTRATE-MIMICKING INHIBITOR / ANTIMICROBIAL AGENT / DRUG DESIGN / SUBSTRATE SPECIFICITY / ACTIVE-SITE ARCHITECTURE |
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