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TitleDevelopment of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
Journal, issue, pagesJ. Med. Chem., Vol. 44, Page 1060-1071, Year 2001
Publish dateJan 18, 2001 (structure data deposition date)
AuthorsNatchus, M.G. / Bookland, R.G. / Laufersweiler, M.J. / Pikul, S. / Almstead, N.G. / De, B. / Janusz, M.J. / Hsieh, L.C. / Gu, F. / Pokross, M.E. ...Natchus, M.G. / Bookland, R.G. / Laufersweiler, M.J. / Pikul, S. / Almstead, N.G. / De, B. / Janusz, M.J. / Hsieh, L.C. / Gu, F. / Pokross, M.E. / Patel, V.S. / Garver, S.M. / Peng, S.X. / Branch, T.M. / King, S.L. / Baker, T.R. / Foltz, D.J. / Mieling, G.E.
External linksJ. Med. Chem. / PubMed:11297453
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-1hy7:
A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-MBS:
R-2-{[4'-METHOXY-(1,1'-BIPHENYL)-4-YL]-SULFONYL}-AMINO-6-METHOXY-HEX-4-YNOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / mixed alpha beta structure / zinc protease / inhibited

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