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TitleThe discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 11, Page 895-898, Year 2001
Publish dateJan 8, 2001 (structure data deposition date)
AuthorsMacdonald, S.J. / Dowle, M.D. / Harrison, L.A. / Shah, P. / Johnson, M.R. / Inglis, G.G. / Clarke, G.D. / Smith, R.A. / Humphreys, D. / Molloy, C.R. ...Macdonald, S.J. / Dowle, M.D. / Harrison, L.A. / Shah, P. / Johnson, M.R. / Inglis, G.G. / Clarke, G.D. / Smith, R.A. / Humphreys, D. / Molloy, C.R. / Amour, A. / Dixon, M. / Murkitt, G. / Godward, R.E. / Padfield, T. / Skarzynski, T. / Singh, O.M. / Kumar, K.A. / Fleetwood, G. / Hodgson, S.T. / Hardy, G.W. / Finch, H.
External linksBioorg. Med. Chem. Lett. / PubMed:11294386
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-1hv7:
PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-616:
N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
KeywordsHYDROLASE / SERINE PROTEASE-INHIBITOR COMPLEX

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