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TitleStructure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
Journal, issue, pagesJ. Biol. Chem., Vol. 276, Page 14170-14177, Year 2001
Publish dateJan 9, 2001 (structure data deposition date)
AuthorsPhan, J. / Steadman, D.J. / Koli, S. / Ding, W.C. / Minor, W. / Dunlap, R.B. / Berger, S.H. / Lebioda, L.
External linksPubMed:11278511
MethodsX-ray diffraction
Resolution2 - 2.06 Å
Structure data

PDB-1hw3:
STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1hw4:
STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Thymidylate Synthase / methyltransferase

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