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TitleMapping the Ribonucleolytic Active Site of Eosinophil-Derived Neurotoxin (Edn): High Resolution Crystal Structures of Edn Complexes with Adenylic Nucleotide Inhibitors
Journal, issue, pagesJ. Biol. Chem., Vol. 276, Page 15009-, Year 2001
Publish dateJan 2, 2001 (structure data deposition date)
AuthorsLeonidas, D.D. / Boix, E. / Prill, R. / Suzuki, M. / Turton, R. / Minson, K. / Swaminathan, G.J. / Youle, R.J. / Acharya, K.R.
External linksJ. Biol. Chem. / PubMed:11154698
MethodsX-ray diffraction
Resolution1.6 - 1.8 Å
Structure data

PDB-1hi2:
Eosinophil-derived Neurotoxin (EDN) - Sulphate Complex
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1hi3:
Eosinophil-derived Neurotoxin (EDN) - Adenosine 2'-5'-Diphosphate Complex
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1hi4:
Eosinophil-derived Neurotoxin (EDN) - Adenosien-3'-5'-Diphosphate Complex
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1hi5:
Eosinophil-derived Neurotoxin (EDN) - Adenosine-5'-Diphosphate Complex
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-A2P:
ADENOSINE-2'-5'-DIPHOSPHATE

ChemComp-A3P:
ADENOSINE-3'-5'-DIPHOSPHATE

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / RNASE-2 / RNASE US / RIBONUCLEASE

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