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TitlePrevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Journal, issue, pagesScience, Vol. 291, Page 134-137, Year 2001
Publish dateSep 20, 2000 (structure data deposition date)
AuthorsDavis, S.T. / Benson, B.G. / Bramson, H.N. / Chapman, D.E. / Dickerson, S.H. / Dold, K.M. / Eberwein, D.J. / Edelstein, M. / Frye, S.V. / Gampe Jr, R.T. ...Davis, S.T. / Benson, B.G. / Bramson, H.N. / Chapman, D.E. / Dickerson, S.H. / Dold, K.M. / Eberwein, D.J. / Edelstein, M. / Frye, S.V. / Gampe Jr, R.T. / Griffin, R.J. / Harris, P.A. / Hassell, A.M. / Holmes, W.D. / Hunter, R.N. / Knick, V.B. / Lackey, K. / Lovejoy, B. / Luzzio, M.J. / Murray, D. / Parker, P. / Rocque, W.J. / Shewchuk, L. / Veal, J.M. / Walker, D.H. / Kuyper, L.F.
External linksScience / PubMed:11141566
MethodsX-ray diffraction
Resolution2.2 - 2.8 Å
Structure data

PDB-1fvt:
THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1fvv:
THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-106:
4-[(2Z)-2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazinyl]benzene-1-sulfonamide

ChemComp-HOH:
WATER

ChemComp-107:
4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CELL CYCLE / cyclin-dependent kinase / oxindole / cyclin A

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