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-Structure paper
タイトル | Structure of the 30S ribosomal subunit. |
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ジャーナル・号・ページ | Nature, Vol. 407, Issue 6802, Page 327-339, Year 2000 |
掲載日 | 2000年9月21日 |
![]() | B T Wimberly / D E Brodersen / W M Clemons / R J Morgan-Warren / A P Carter / C Vonrhein / T Hartsch / V Ramakrishnan / ![]() |
PubMed 要旨 | Genetic information encoded in messenger RNA is translated into protein by the ribosome, which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in bacteria. Here we ...Genetic information encoded in messenger RNA is translated into protein by the ribosome, which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in bacteria. Here we report the crystal structure of the 30S subunit from Thermus thermophilus, refined to 3 A resolution. The final atomic model rationalizes over four decades of biochemical data on the ribosome, and provides a wealth of information about RNA and protein structure, protein-RNA interactions and ribosome assembly. It is also a structural basis for analysis of the functions of the 30S subunit, such as decoding, and for understanding the action of antibiotics. The structure will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography. |
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手法 | X線回折 |
解像度 | 3.05 Å |
構造データ | ![]() PDB-1j5e: |
化合物 | ![]() ChemComp-UNX: ![]() ChemComp-ZN: |
由来 |
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![]() | RIBOSOME / 30S RIBOSOMAL SUBUNIT |