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Title(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 97, Page 5113-5118, Year 2000
Publish dateApr 22, 2000 (structure data deposition date)
AuthorsSperl, S. / Jacob, U. / Arroyo de Prada, N. / Sturzebecher, J. / Wilhelm, O.G. / Bode, W. / Magdolen, V. / Huber, R. / Moroder, L.
External linksProc. Natl. Acad. Sci. USA / PubMed:10805774
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-1ejn:
UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN INHIBITOR COMPLEX
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-AGB:
N-(1-ADAMANTYL)-N'-(4-GUANIDINOBENZYL)UREA

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / human / upa / plasminogen activator / urokinase / inhibitor complex

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