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TitleMutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release.
Journal, issue, pagesBiochemistry, Vol. 39, Page 1211-1216, Year 2000
Publish dateJan 12, 2000 (structure data deposition date)
AuthorsMacGillivray, R.T. / Bewley, M.C. / Smith, C.A. / He, Q.Y. / Mason, A.B.
External linksBiochemistry / PubMed:10684598
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-1dtg:
HUMAN TRANSFERRIN N-LOBE MUTANT H249E
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-FE:
Unknown entry

ChemComp-CO3:
CARBONATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMETAL TRANSPORT / IRON TRANSPORT / GLYCOPROTEIN / METAL-BINDING / POLYMORPHISM / 3D- STRUCTURE

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