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-Structure paper
Title | Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 97, Page 1506-1511, Year 2000 |
Publish date | Nov 8, 1999 (structure data deposition date) |
Authors | McMillan, K. / Adler, M. / Auld, D.S. / Baldwin, J.J. / Blasko, E. / Browne, L.J. / Chelsky, D. / Davey, D. / Dolle, R.E. / Eagen, K.A. ...McMillan, K. / Adler, M. / Auld, D.S. / Baldwin, J.J. / Blasko, E. / Browne, L.J. / Chelsky, D. / Davey, D. / Dolle, R.E. / Eagen, K.A. / Erickson, S. / Feldman, R.I. / Glaser, C.B. / Mallari, C. / Morrissey, M.M. / Ohlmeyer, M.H. / Pan, G. / Parkinson, J.F. / Phillips, G.B. / Polokoff, M.A. / Sigal, N.H. / Vergona, R. / Whitlow, M. / Young, T.A. / Devlin, J.J. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:10677491 |
Methods | X-ray diffraction |
Resolution | 2.25 Å |
Structure data | PDB-1dd7: |
Chemicals | ChemComp-SO3: ChemComp-HEM: ChemComp-1PM: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / NITRIC OXIDE / L-ARGININE MONOOXYGENASE / HEME / DIMERIZATION / INHIBITOR / NOS |