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TitleDrug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Journal, issue, pagesMol. Pharmacol., Vol. 57, Page 359-366, Year 2000
Publish dateJun 7, 1999 (structure data deposition date)
AuthorsFantz, C. / Shaw, D. / Jennings, W. / Forsthoefel, A. / Kitchens, M. / Phan, J. / Minor, W. / Lebioda, L. / Berger, F.G. / Spencer, H.T.
External linksPubMed:10648646
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-1qqq:
CRYSTAL STRUCTURE ANALYSIS OF SER254 MUTANT OF ESCHERICHIA COLI THYMIDYLATE SYNTHASE
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / THYMIDYLATE SYNTHASE / METHYLTRANSFERASE

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