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TitleStructural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.
Journal, issue, pagesNucleic Acids Res., Vol. 28, Page 710-719, Year 2000
Publish dateFeb 23, 2000 (structure data deposition date)
AuthorsVarani, L. / Spillantini, M.G. / Goedert, M. / Varani, G.
External linksNucleic Acids Res. / PubMed:10637322
MethodsNMR (solution)
Structure data

PDB-1ei2:
STRUCTURAL BASIS FOR RECOGNITION OF THE RNA MAJOR GROOVE IN THE TAU EXON 10 SPLICING REGULATORY ELEMENT BY AMINOGLYCOSIDE ANTIBIOTICS
Method: SOLUTION NMR

Chemicals

ChemComp-NMY:
NEOMYCIN / antibiotic*YM

KeywordsRNA / tau / frontotemporal dementia FTDP-17 / intronic mutations / aminoglycoside / RNA major groove recognition

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