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TitleDehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.
Journal, issue, pagesJ. Biol. Chem., Vol. 275, Page 1105-1111, Year 2000
Publish dateMar 25, 1998 (structure data deposition date)
AuthorsHan, Q. / Campbell, R.L. / Gangloff, A. / Huang, Y.W. / Lin, S.X.
External linksJ. Biol. Chem. / PubMed:10625652
MethodsX-ray diffraction
Resolution2.24 - 2.3 Å
Structure data

PDB-1dht:
ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED DIHYDROTESTOSTERONE
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

PDB-3dhe:
ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED DEHYDROEPIANDROSTERONE
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-DHT:
5-ALPHA-DIHYDROTESTOSTERONE / hormone*YM

ChemComp-HOH:
WATER

ChemComp-AND:
3-BETA-HYDROXY-5-ANDROSTEN-17-ONE / hormone*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / SHORT-CHAIN DEHYDROGENASE / STEROID / DIHYDROTESTOSTERONE / DHT / DEHYDROEPIANDROSTERONE / DHEA / ANDROGEN

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