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Structure paper

TitleInhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 266, Page 411-416, Year 1999
Publish dateAug 24, 1999 (structure data deposition date)
AuthorsTsuge, H. / Nishimura, T. / Tada, Y. / Asao, T. / Turk, D. / Turk, V. / Katunuma, N.
External linksBiochem. Biophys. Res. Commun. / PubMed:10600517
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-1cvz:
CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-C48:
N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE

ChemComp-HOH:
WATER

Source
  • carica papaya (papaya)
KeywordsHYDROLASE / PAPAIN / CLIK148 / CATHEPSIN L INHIBITOR / SULFHYDRYL PROTEINASE

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