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Structure paper

TitleSelection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
Journal, issue, pagesJ. Mol. Biol., Vol. 293, Page 865-881, Year 1999
Publish dateSep 1, 1999 (structure data deposition date)
AuthorsChen, Y. / Wiesmann, C. / Fuh, G. / Li, B. / Christinger, H.W. / McKay, P. / de Vos, A.M. / Lowman, H.B.
External linksJ. Mol. Biol. / PubMed:10543973
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-1cz8:
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / COMPLEX (ANTIBODY-ANTIGEN) / CYSTINE KNOT / FAB FRAGMENT

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