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TitleThe variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop
Journal, issue, pagesJ. Mol. Biol., Vol. 293, Page 613-627, Year 1999
Publish dateDec 11, 1998 (structure data deposition date)
AuthorsDekker, R.J. / Eichinger, A. / Stoop, A.A. / Bode, W. / Pannekoek, H. / Horrevoets, A.J.G.
External linksJ. Mol. Biol. / PubMed:10543954
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1vr1:
Specifity for Plasminogen Activator Inhibitor-1
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • hirudo medicinalis (medicinal leech)
KeywordsBLOOD CLOTTING/HYDROLASE INHIBITOR / THROMBIN / BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX

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