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TitleKinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan.
Journal, issue, pagesBiochemistry, Vol. 38, Page 12514-12525, Year 1999
Publish dateApr 20, 1999 (structure data deposition date)
AuthorsWard, W.H. / Holdgate, G.A. / Rowsell, S. / McLean, E.G. / Pauptit, R.A. / Clayton, E. / Nichols, W.W. / Colls, J.G. / Minshull, C.A. / Jude, D.A. ...Ward, W.H. / Holdgate, G.A. / Rowsell, S. / McLean, E.G. / Pauptit, R.A. / Clayton, E. / Nichols, W.W. / Colls, J.G. / Minshull, C.A. / Jude, D.A. / Mistry, A. / Timms, D. / Camble, R. / Hales, N.J. / Britton, C.J. / Taylor, I.W.
External linksBiochemistry / PubMed:10493822
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1qg6:
CRYSTAL STRUCTURE OF E. COLI ENOYL ACYL CARRIER PROTEIN REDUCTASE IN COMPLEX WITH NAD AND TRICLOSAN
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-TCL:
TRICLOSAN / antifungal, antibiotic, detergent*YM

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsOXIDOREDUCTASE / FATTY ACID SYNTHESIS / ANTIBACTERIAL

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