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Open data
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Basic information
Entry | ![]() | |||||||||
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Title | Human muscle nAChR ACh-bound state | |||||||||
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![]() | human muscle / nicotinic acetylcholine receptor / MEMBRANE PROTEIN | |||||||||
Function / homology | ![]() postsynaptic membrane organization / skeletal muscle tissue growth / musculoskeletal movement / Highly sodium permeable postsynaptic acetylcholine nicotinic receptors / Highly calcium permeable nicotinic acetylcholine receptors / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / acetylcholine receptor activity / acetylcholine-gated channel complex / neuromuscular synaptic transmission / behavioral response to nicotine ...postsynaptic membrane organization / skeletal muscle tissue growth / musculoskeletal movement / Highly sodium permeable postsynaptic acetylcholine nicotinic receptors / Highly calcium permeable nicotinic acetylcholine receptors / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / acetylcholine receptor activity / acetylcholine-gated channel complex / neuromuscular synaptic transmission / behavioral response to nicotine / acetylcholine-gated monoatomic cation-selective channel activity / muscle cell development / acetylcholine binding / nervous system process / synaptic transmission, cholinergic / monoatomic cation transmembrane transporter activity / acetylcholine receptor signaling pathway / postsynaptic specialization membrane / muscle cell cellular homeostasis / neuromuscular process / neuromuscular junction development / ligand-gated monoatomic ion channel activity / monoatomic cation transport / membrane depolarization / skeletal muscle contraction / neuronal action potential / muscle contraction / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / regulation of membrane potential / response to nicotine / neuromuscular junction / neuron cellular homeostasis / transmembrane signaling receptor activity / channel activity / postsynaptic membrane / neuron projection / synapse / cell surface / signal transduction / plasma membrane Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | single particle reconstruction / cryo EM / Resolution: 2.06 Å | |||||||||
![]() | Li H / Hibbs RE | |||||||||
Funding support | ![]()
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![]() | ![]() Title: Structure of human muscle AChR ACh-bound state Authors: Li H / Hibbs RE | |||||||||
History |
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Structure visualization
Supplemental images |
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Downloads & links
-EMDB archive
Map data | ![]() | 230.3 MB | ![]() | |
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Header (meta data) | ![]() ![]() | 20.9 KB 20.9 KB | Display Display | ![]() |
FSC (resolution estimation) | ![]() | 13.1 KB | Display | ![]() |
Images | ![]() | 139 KB | ||
Filedesc metadata | ![]() | 7.1 KB | ||
Others | ![]() ![]() | 226.5 MB 226.5 MB | ||
Archive directory | ![]() ![]() | HTTPS FTP |
-Validation report
Summary document | ![]() | 870 KB | Display | ![]() |
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Full document | ![]() | 869.5 KB | Display | |
Data in XML | ![]() | 21.9 KB | Display | |
Data in CIF | ![]() | 28.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 9dmhMC M: atomic model generated by this map C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
EMDB pages | ![]() ![]() |
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Related items in Molecule of the Month |
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Map
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Projections & slices | Image control
Images are generated by Spider. | ||||||||||||||||||||||||||||||||||||
Voxel size | X=Y=Z: 0.935 Å | ||||||||||||||||||||||||||||||||||||
Density |
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Symmetry | Space group: 1 | ||||||||||||||||||||||||||||||||||||
Details | EMDB XML:
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-Supplemental data
-Half map: #2
File | emd_47005_half_map_1.map | ||||||||||||
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Projections & Slices |
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Density Histograms |
-Half map: #1
File | emd_47005_half_map_2.map | ||||||||||||
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Projections & Slices |
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Density Histograms |
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Sample components
-Entire : Human muscle nicotinic acetylcholine receptor
Entire | Name: Human muscle nicotinic acetylcholine receptor |
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Components |
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-Supramolecule #1: Human muscle nicotinic acetylcholine receptor
Supramolecule | Name: Human muscle nicotinic acetylcholine receptor / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#4 |
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Source (natural) | Organism: ![]() |
-Macromolecule #1: Acetylcholine receptor subunit alpha
Macromolecule | Name: Acetylcholine receptor subunit alpha / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO |
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Source (natural) | Organism: ![]() |
Molecular weight | Theoretical: 51.889266 KDa |
Recombinant expression | Organism: ![]() |
Sequence | String: MEPWPLLLLF SLCSAGLVLG SEHETRLVAK LFKDYSSVVR PVEDHRQVVE VTVGLQLIQL INVDEVNQIV TTNVRLKQQW VDYNLKWNP DDYGGVKKIH IPSEKIWRPD LVLYNNADGD FAIVKFTKVL LQYTGHITWT PPAIFKSYCE IIVTHFPFDE Q NCSMKLGT ...String: MEPWPLLLLF SLCSAGLVLG SEHETRLVAK LFKDYSSVVR PVEDHRQVVE VTVGLQLIQL INVDEVNQIV TTNVRLKQQW VDYNLKWNP DDYGGVKKIH IPSEKIWRPD LVLYNNADGD FAIVKFTKVL LQYTGHITWT PPAIFKSYCE IIVTHFPFDE Q NCSMKLGT WTYDGSVVAI NPESDQPDLS NFMESGEWVI KESRGWKHSV TYSCCPDTPY LDITYHFVMQ RLPLYFIVNV II PCLLFSF LTGLVFYLPT DSGEKMTLSI SVLLSLTVFL LVIVELIPST SSAVPLIGKY MLFTMVFVIA SIIITVIVIN THH RSPSTH VMPNWVRKVF IDTIPNIMFF STMKRPSREK QDKKIFTEDI DISDISGKPG PPPMGFHSPL IKHPEVKSAI EGIK YIAET MKSDQESNNA AAEWKYVAMV MDHILLGVFM LVCIIGTLAV FAGRLIELNQ QG UniProtKB: Acetylcholine receptor subunit alpha |
-Macromolecule #2: Acetylcholine receptor subunit beta
Macromolecule | Name: Acetylcholine receptor subunit beta / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO |
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Source (natural) | Organism: ![]() |
Molecular weight | Theoretical: 57.00041 KDa |
Recombinant expression | Organism: ![]() |
Sequence | String: MTPGALLMLL GALGAPLAPG VRGSEAEGRL REKLFSGYDS SVRPAREVGD RVRVSVGLIL AQLISLNEKD EEMSTKVYLD LEWTDYRLS WDPAEHDGID SLRITAESVW LPDVVLLNNN DGNFDVALDI SVVVSSDGSV RWQPPGIYRS SCSIQVTYFP F DWQNCTMV ...String: MTPGALLMLL GALGAPLAPG VRGSEAEGRL REKLFSGYDS SVRPAREVGD RVRVSVGLIL AQLISLNEKD EEMSTKVYLD LEWTDYRLS WDPAEHDGID SLRITAESVW LPDVVLLNNN DGNFDVALDI SVVVSSDGSV RWQPPGIYRS SCSIQVTYFP F DWQNCTMV FSSYSYDSSE VSLQTGLGPD GQGHQEIHIH EGTFIENGQW EIIHKPSRLI QPPGDPRGGR EGQRQEVIFY LI IRRKPLF YLVNVIAPCI LITLLAIFVF YLPPDAGEKM GLSIFALLTL TVFLLLLADK VPETSLSVPI IIKYLMFTMV LVT FSVILS VVVLNLHHRS PHTHQMPLWV RQIFIHKLPL YLRLKRPKPE RDLMPEPPHC SSPGSGWGRG TDEYFIRKPP SDFL FPKPN RFQPELSAPD LRRFIDGPNR AVALLPELRE VVSSISYIAR QLQEQEDHDA LKEDWQFVAM VVDRLFLWTF IIFTS VGTL VIFLDATYHL PPPDPFPSR UniProtKB: Acetylcholine receptor subunit beta |
-Macromolecule #3: Acetylcholine receptor subunit delta
Macromolecule | Name: Acetylcholine receptor subunit delta / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO |
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Source (natural) | Organism: ![]() |
Molecular weight | Theoretical: 58.955805 KDa |
Recombinant expression | Organism: ![]() |
Sequence | String: MEGPVLTLGL LAALAVCGSW GLNEEERLIR HLFQEKGYNK ELRPVAHKEE SVDVALALTL SNLISLKEVE ETLTTNVWIE HGWTDNRLK WNAEEFGNIS VLRLPPDMVW LPEIVLENNN DGSFQISYSC NVLVYHYGFV YWLPPAIFRS SCPISVTYFP F DWQNCSLK ...String: MEGPVLTLGL LAALAVCGSW GLNEEERLIR HLFQEKGYNK ELRPVAHKEE SVDVALALTL SNLISLKEVE ETLTTNVWIE HGWTDNRLK WNAEEFGNIS VLRLPPDMVW LPEIVLENNN DGSFQISYSC NVLVYHYGFV YWLPPAIFRS SCPISVTYFP F DWQNCSLK FSSLKYTAKE ITLSLKQDAK ENRTYPVEWI IIDPEGFTEN GEWEIVHRPA RVNVDPRAPL DSPSRQDITF YL IIRRKPL FYIINILVPC VLISFMVNLV FYLPADSGEK TSVAISVLLA QSVFLLLISK RLPATSMAIP LIGKFLLFGM VLV TMVVVI CVIVLNIHFR TPSTHVLSEG VKKLFLETLP ELLHMSRPAE DGPSPGALVR RSSSLGYISK AEEYFLLKSR SDLM FEKQS ERHGLARRLT TARRPPASSE QAQQELFNEL KPAVDGANFI VNHMRDQNNY NEEKDSWNRV ARTVDRLCLF VVTPV MVVG TAWIFLQGVY NQPPPQPFPG DPYSYNVQDK RFI UniProtKB: Acetylcholine receptor subunit delta |
-Macromolecule #4: Acetylcholine receptor subunit epsilon
Macromolecule | Name: Acetylcholine receptor subunit epsilon / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO |
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Source (natural) | Organism: ![]() |
Molecular weight | Theoretical: 54.743754 KDa |
Recombinant expression | Organism: ![]() |
Sequence | String: MARAPLGVLL LLGLLGRGVG KNEELRLYHH LFNNYDPGSR PVREPEDTVT ISLKVTLTNL ISLNEKEETL TTSVWIGIDW QDYRLNYSK DDFGGIETLR VPSELVWLPE IVLENNIDGQ FGVAYDANVL VYEGGSVTWL PPAIYRSVCA VEVTYFPFDW Q NCSLIFRS ...String: MARAPLGVLL LLGLLGRGVG KNEELRLYHH LFNNYDPGSR PVREPEDTVT ISLKVTLTNL ISLNEKEETL TTSVWIGIDW QDYRLNYSK DDFGGIETLR VPSELVWLPE IVLENNIDGQ FGVAYDANVL VYEGGSVTWL PPAIYRSVCA VEVTYFPFDW Q NCSLIFRS QTYNAEEVEF TFAVDNDGKT INKIDIDTEA YTENGEWAID FCPGVIRRHH GGATDGPGET DVIYSLIIRR KP LFYVINI IVPCVLISGL VLLAYFLPAQ AGGQKCTVSI NVLLAQTVFL FLIAQKIPET SLSVPLLGRF LIFVMVVATL IVM NCVIVL NVSQRTPTTH AMSPRLRHVL LELLPRLLGS PPPPEAPRAA SPPRRASSVG LLLRAEELIL KKPRSELVFE GQRH RQGTW TAAFCQSLGA AAPEVRCCVD AVNFVAESTR DQEATGEEVS DWVRMGNALD NICFWAALVL FSVGSSLIFL GAYFN RVPD LPYAPCIQP UniProtKB: Acetylcholine receptor subunit epsilon |
-Macromolecule #10: ACETYLCHOLINE
Macromolecule | Name: ACETYLCHOLINE / type: ligand / ID: 10 / Number of copies: 2 / Formula: ACH |
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Molecular weight | Theoretical: 146.207 Da |
Chemical component information | ![]() ChemComp-ACH: |
-Macromolecule #11: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(tri...
Macromolecule | Name: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate type: ligand / ID: 11 / Number of copies: 3 / Formula: POV |
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Molecular weight | Theoretical: 760.076 Da |
Chemical component information | ![]() ChemComp-POV: |
-Macromolecule #12: water
Macromolecule | Name: water / type: ligand / ID: 12 / Number of copies: 2 / Formula: HOH |
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Molecular weight | Theoretical: 18.015 Da |
Chemical component information | ![]() ChemComp-HOH: |
-Experimental details
-Structure determination
Method | cryo EM |
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![]() | single particle reconstruction |
Aggregation state | particle |
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Sample preparation
Buffer | pH: 7.4 |
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Vitrification | Cryogen name: ETHANE |
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Electron microscopy
Microscope | FEI TITAN KRIOS |
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Image recording | Film or detector model: FEI FALCON III (4k x 4k) / Average electron dose: 50.0 e/Å2 |
Electron beam | Acceleration voltage: 300 kV / Electron source: ![]() |
Electron optics | Illumination mode: OTHER / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.0 µm / Nominal defocus min: 1.4000000000000001 µm |
Experimental equipment | ![]() Model: Titan Krios / Image courtesy: FEI Company |