Entry Database : EMDB / ID : EMD-43196 Downloads & linksTitle Cryo-EM structure of GATA4 in complex with ALBN1 nucleosome Map datamain map Details SampleComplex : GATA4 in complex with 186bp ALBN1 nucleosomeDNA : DNA (159-MER)DNA : DNA (159-MER)Protein or peptide : Histone H3.1Protein or peptide : Histone H4Protein or peptide : Histone H2A type 1-B/EProtein or peptide : Histone H2B type 1-JProtein or peptide : Maltose/maltodextrin-binding periplasmic protein,Transcription factor GATA-4 Show more 3 items Show lessLigand : ZINC ION Details Keywords nucleosome / pioneer transcription factors / DNA binding proteins / transcription / chromatin / NUCLEAR PROTEIN / NUCLEAR PROTEIN-DNA complexFunction / homology Function and homology informationFunction Domain/homology Component
: / atrial septum secundum morphogenesis / DNA-binding transcription factor binding => GO:0140297 / RNA polymerase II-specific DNA-binding transcription factor binding => GO:0061629 / atrioventricular valve formation / transdifferentiation / embryonic heart tube anterior/posterior pattern specification / positive regulation of cardioblast differentiation / intestinal epithelial cell differentiation / cardiac right ventricle morphogenesis ... : / atrial septum secundum morphogenesis / DNA-binding transcription factor binding => GO:0140297 / RNA polymerase II-specific DNA-binding transcription factor binding => GO:0061629 / atrioventricular valve formation / transdifferentiation / embryonic heart tube anterior/posterior pattern specification / positive regulation of cardioblast differentiation / intestinal epithelial cell differentiation / cardiac right ventricle morphogenesis / co-SMAD binding / cell growth involved in cardiac muscle cell development / atrial septum morphogenesis / cardiac muscle tissue regeneration / endocardial cushion development / cardiac ventricle morphogenesis / Physiological factors / response to xenobiotic stimulus => GO:0009410 / atrial septum primum morphogenesis / embryonic foregut morphogenesis / chromatin => GO:0000785 / YAP1- and WWTR1 (TAZ)-stimulated gene expression / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / endoderm development / positive regulation of BMP signaling pathway / response to vitamin A / regulation of cardiac muscle cell contraction / aortic valve morphogenesis / ventricular septum development / negative regulation of cardiac muscle cell apoptotic process / detection of maltose stimulus / maltose transport complex / NFAT protein binding / heart looping / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / carbohydrate transport / transcription factor binding / negative regulation of apoptotic signaling pathway / carbohydrate transmembrane transporter activity / maltose binding / maltose transport / maltodextrin transmembrane transport / negative regulation of tumor necrosis factor-mediated signaling pathway / positive regulation of vascular endothelial growth factor production / negative regulation of megakaryocyte differentiation / cell fate commitment / protein localization to CENP-A containing chromatin / Chromatin modifying enzymes / Replacement of protamines by nucleosomes in the male pronucleus / CENP-A containing nucleosome / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / Packaging Of Telomere Ends / response to mechanical stimulus / epigenetic regulation of gene expression / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / nucleosomal DNA binding / Deposition of new CENPA-containing nucleosomes at the centromere / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Inhibition of DNA recombination at telomere / Meiotic synapsis / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling / ATP-binding cassette (ABC) transporter complex / negative regulation of autophagy / Assembly of the ORC complex at the origin of replication / SUMOylation of chromatin organization proteins / DNA methylation / Condensation of Prophase Chromosomes / cell chemotaxis / SIRT1 negatively regulates rRNA expression / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / HCMV Late Events / innate immune response in mucosa / PRC2 methylates histones and DNA / Defective pyroptosis / HDACs deacetylate histones / cellular response to glucose stimulus / lipopolysaccharide binding / RNA Polymerase I Promoter Escape / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Nonhomologous End-Joining (NHEJ) / Transcriptional regulation by small RNAs / heterochromatin formation / Formation of the beta-catenin:TCF transactivating complex / wound healing / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / NoRC negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / G2/M DNA damage checkpoint / HDMs demethylate histones / B-WICH complex positively regulates rRNA expression / DNA Damage/Telomere Stress Induced Senescence / Metalloprotease DUBs / PKMTs methylate histone lysines / Meiotic recombination / RMTs methylate histone arginines Similarity search - Function GATA-type transcription activator, N-terminal / Transcription factor GATA-4/5/6 / GATA-type transcription activator, N-terminal / Transcription factor GATA / GATA-type zinc finger domain. / GATA-type zinc finger domain profile. / zinc finger binding to DNA consensus sequence [AT]GATA[AG] / GATA zinc finger / Zinc finger, GATA-type / Maltose/Cyclodextrin ABC transporter, substrate-binding protein ... GATA-type transcription activator, N-terminal / Transcription factor GATA-4/5/6 / GATA-type transcription activator, N-terminal / Transcription factor GATA / GATA-type zinc finger domain. / GATA-type zinc finger domain profile. / zinc finger binding to DNA consensus sequence [AT]GATA[AG] / GATA zinc finger / Zinc finger, GATA-type / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein / Histone H2B signature. / Histone H2B / Histone H2B / Histone H2A conserved site / Histone H2A signature. / Histone H2A, C-terminal domain / C-terminus of histone H2A / Histone H2A / Histone 2A / Histone H4, conserved site / Histone H4 signature. / Histone H4 / Histone H4 / TATA box binding protein associated factor / TATA box binding protein associated factor (TAF), histone-like fold domain / CENP-T/Histone H4, histone fold / Centromere kinetochore component CENP-T histone fold / Histone H3 signature 1. / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Zinc finger, NHR/GATA-type / Histone-fold Similarity search - Domain/homology Histone H2A type 1-B/E / Histone H2B type 1-J / Maltose/maltodextrin-binding periplasmic protein / Transcription factor GATA-4 / Histone H4 / Histone H3.1 Similarity search - ComponentBiological species Homo sapiens (human) / synthetic construct (others) Method single particle reconstruction / cryo EM / Resolution : 3.07 Å Details AuthorsZhou BR / Bai Y Funding support United States, 1 items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) Intramural Research Program United States
CitationJournal : Mol.Cell / Year : 2024Title : Cryo-EM structure of GATA4 in complex with ALBN1 nucleosomeAuthors : Zhou BR / Bai Y History Deposition Dec 22, 2023 - Header (metadata) release Aug 7, 2024 - Map release Aug 7, 2024 - Update Aug 7, 2024 - Current status Aug 7, 2024 Processing site : RCSB / Status : Released
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