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Yorodumi- EMDB-26560: Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in ... -
+Open data
-Basic information
Entry | Database: EMDB / ID: EMD-26560 | |||||||||
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Title | Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab | |||||||||
Map data | Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab | |||||||||
Sample |
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Biological species | Severe acute respiratory syndrome coronavirus 2 / Homo sapiens (human) | |||||||||
Method | single particle reconstruction / cryo EM / Resolution: 3.8 Å | |||||||||
Authors | Pankaj P / Robb C / Scortecci JF | |||||||||
Funding support | United States, 1 items
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Citation | Journal: To Be Published Title: LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants Authors: Pankaj P | |||||||||
History |
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-Structure visualization
Supplemental images |
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-Downloads & links
-EMDB archive
Map data | emd_26560.map.gz | 228.9 MB | EMDB map data format | |
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Header (meta data) | emd-26560-v30.xml emd-26560.xml | 11.7 KB 11.7 KB | Display Display | EMDB header |
FSC (resolution estimation) | emd_26560_fsc.xml | 18.3 KB | Display | FSC data file |
Images | emd_26560.png | 58.2 KB | ||
Others | emd_26560_half_map_1.map.gz emd_26560_half_map_2.map.gz | 194 MB 194 MB | ||
Archive directory | http://ftp.pdbj.org/pub/emdb/structures/EMD-26560 ftp://ftp.pdbj.org/pub/emdb/structures/EMD-26560 | HTTPS FTP |
-Validation report
Summary document | emd_26560_validation.pdf.gz | 1001.5 KB | Display | EMDB validaton report |
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Full document | emd_26560_full_validation.pdf.gz | 1001.1 KB | Display | |
Data in XML | emd_26560_validation.xml.gz | 21.3 KB | Display | |
Data in CIF | emd_26560_validation.cif.gz | 28.2 KB | Display | |
Arichive directory | https://ftp.pdbj.org/pub/emdb/validation_reports/EMD-26560 ftp://ftp.pdbj.org/pub/emdb/validation_reports/EMD-26560 | HTTPS FTP |
-Links
EMDB pages | EMDB (EBI/PDBe) / EMDataResource |
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-Map
File | Download / File: emd_26560.map.gz / Format: CCP4 / Size: 244.1 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) | ||||||||||||||||||||||||||||||||||||
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Annotation | Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab | ||||||||||||||||||||||||||||||||||||
Projections & slices | Image control
Images are generated by Spider. | ||||||||||||||||||||||||||||||||||||
Voxel size | X=Y=Z: 0.98 Å | ||||||||||||||||||||||||||||||||||||
Density |
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Symmetry | Space group: 1 | ||||||||||||||||||||||||||||||||||||
Details | EMDB XML:
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-Supplemental data
-Half map: Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein...
File | emd_26560_half_map_1.map | ||||||||||||
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Annotation | Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab | ||||||||||||
Projections & Slices |
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Density Histograms |
-Half map: Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein...
File | emd_26560_half_map_2.map | ||||||||||||
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Annotation | Cryo-EM structure of SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab | ||||||||||||
Projections & Slices |
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Density Histograms |
-Sample components
-Entire : SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab
Entire | Name: SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab |
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Components |
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-Supramolecule #1: SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab
Supramolecule | Name: SARS-CoV-2 Alpha (B.1.1.7) spike protein in complex with bebtelovimab type: complex / ID: 1 / Chimera: Yes / Parent: 0 |
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-Supramolecule #2: SARS-CoV-2 Alpha (B.1.1.7) spike protein
Supramolecule | Name: SARS-CoV-2 Alpha (B.1.1.7) spike protein / type: complex / ID: 2 / Chimera: Yes / Parent: 1 |
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Source (natural) | Organism: Severe acute respiratory syndrome coronavirus 2 |
-Supramolecule #3: Monoclonal antibody bebtelovimab
Supramolecule | Name: Monoclonal antibody bebtelovimab / type: complex / ID: 3 / Chimera: Yes / Parent: 2 |
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Source (natural) | Organism: Homo sapiens (human) |
-Experimental details
-Structure determination
Method | cryo EM |
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Processing | single particle reconstruction |
Aggregation state | particle |
-Sample preparation
Buffer | pH: 7.4 |
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Vitrification | Cryogen name: ETHANE |
-Electron microscopy
Microscope | FEI TITAN |
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Image recording | Film or detector model: FEI FALCON IV (4k x 4k) / Average electron dose: 40.0 e/Å2 |
Electron beam | Acceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN |
Electron optics | Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 3.5 µm / Nominal defocus min: 1.5 µm |